AN UNBIASED VIEW OF LDN-27219 PROTEIN KINASE TARGETING

One particular notably intriguing compound is LDN-27219. Whilst most tTG inhibitors are designed to bind into the protein crosslinking Energetic web page, LDN-27219 as a substitute binds on the nucleotide binding pocket from the enzyme though it can be in its closed-state conformation, and stabilizes that conformation to forestall crosslinking acti